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Pain Paid Clinical Trials in California
A listing of 133 Pain clinical trials in California actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
1 - 12 of 133
The state of California currently has 133 active clinical trials seeking participants for Pain research studies. These trials are conducted in various cities, including Los Angeles, San Francisco, San Diego and Sacramento.
Featured Trial
Paid Clinical Studies Nationwide
Recruiting
Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.
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Conditions:
Overweight
Overweight and Obesity
Obesity
Weight Loss
Morbid Obesity
Evaluation of Efficacy and Safety of Suzetrigine for Pain Associated With Diabetic Peripheral Neuropathy
Recruiting
The purpose of this study is to evaluate the efficacy, safety, and tolerability of Suzetrigine (SUZ) in participants with pain associated with diabetic peripheral neuropathy (DPN).
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
06/25/2025
Locations: Neuro-Pain Medical Center, Fresno, California +7 locations
Conditions: Diabetic Peripheral Neuropathic Pain
Effects of LY3848575 Versus Placebo in Participants With Painful Distal Sensory Polyneuropathy
Recruiting
The purpose of this study is to evaluate how safe and how well a treatment works compared to placebo for people with nerve pain that begins in their feet and moves up the leg to just below the knee.
Participation may last up to 30 weeks including screening.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/24/2025
Locations: Neuro-Pain Medical Center, Fresno, California
Conditions: Neuropathic Pain, Distal Sensory Polyneuropathy
Strain-Counterstrain Treatment of Piriformis Pain
Recruiting
The purpose of this investigator-initiated study is to provide an efficient and non-invasive treatment option for pain caused by the piriformis muscle.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
06/24/2025
Locations: Loma Linda University Health, Loma Linda, California
Conditions: Low Back Pain, Mechanical, Piriformis Syndrome, Somatic Dysfunction of Sacral Region (Finding)
A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain
Recruiting
The purpose of the chronic pain master protocol is to compare independent pain interventions and establish an overarching structure for the disease-state addenda (DSA) and intervention-specific appendices (ISAs). The ISAs may start independently of other ISAs as interventions become available for clinical testing.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/24/2025
Locations: Irvine Clinical Research, Irvine, California +3 locations
Conditions: Osteoarthritis, Knee, Diabetic Neuropathic Pain, Chronic Low-back Pain
Safety, Efficacy, and Frequency of Administration of VNX001 in the Treatment of Interstitial Cystitis / Bladder Pain Syndrome (IC/BPS)
Recruiting
This is an open-label study that will enroll participants with Interstitial Cystitis / Bladder Pain Syndrome (IC/BPS).
The study will assess PRN (as needed) dosing of up to 6 intravesical (via catheter) doses of VNX001 (study drug) to treat acute instances of moderate to severe bladder pain over a 14-day period. The main aim of the study is to tally the number of doses and assess pain before and after doses. The study will review the safety and tolerability of VNX001.
Participants will need to... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/24/2025
Locations: Valley Urology, Inc., Fresno, California +1 locations
Conditions: Interstitial Cystitis, Bladder Pain Syndrome
Evaluation of Efficacy and Safety of VX-993 for Pain Associated With Diabetic Peripheral Neuropathy
Recruiting
The purpose of this study is to evaluate the efficacy, safety, and tolerability of VX-993 in participants with pain associated with Diabetic Peripheral Neuropathy (DPN)
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
06/23/2025
Locations: Trovare Clinical Research, Bakersfield, California +1 locations
Conditions: Diabetic Peripheral Neuropathic Pain
Long-Term Real-World Outcomes Study on Patients Implanted With a Neurostimulator
Recruiting
The REALITY study is a prospective, post-market, non-randomized, multi-center, single-arm, open-label study intended to collect short- and long-term safety and effectiveness data on various populations implanted with Abbott's neurostimulation systems.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/19/2025
Locations: California Orthopedics & Spine, Larkspur, California +3 locations
Conditions: Chronic Pain
Phase I Single Ascending Dose and Multiple Ascending Doses of Oral AFA-281 in Healthy Volunteers
Recruiting
Phase I Part 1 (single ascending dose):
Double-blind dosing will occur in healthy volunteers in 4 cohorts of 8 subjects each. Six subjects in each cohort will be randomized to receive AFA-281 and 2 subjects will be randomized to receive the matching placebo. At the end of the Part 1 study is to evaluate the safety and tolerability of AFA-281. Following completion of each cohort, bioanalytical analyses will be conducted to evaluate the pharmacokinetic profile.
Phase I Part 2 (multiple dose for... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
06/18/2025
Locations: CenExcel CNS, Los Alamitos, California
Conditions: Pain, Neuropathic, Pain, Inflammatory
Examination of Nociscan Impact on Discogenic Low Back Pain Surgical Outcomes
Recruiting
This study is looking into how safe and useful NOCISCAN is. NOCISCAN is a software as a Service (SaaS) tool that uses Magnetic Resonance (MR) spectroscopy. Nociscan (instead of 'It') leverages MRS to noninvasively help physicians distinguish between painful and nonpainful discs in the lumbar spine. The randomized controlled trial will compare the blinded and unblinded cohorts and their corresponding surgical outcomes with the Nocigram reports, generated prior to treatment, for each patient."
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
06/18/2025
Locations: Scripps Health, La Jolla, California
Conditions: Discogenic Low Back Pain
Continuous Versus Single Injection Adductor Canal Blocks for Outpatient Total Knee Arthroplasty
Recruiting
This is a single-center pilot study to determine if an adductor canal continuous nerve block is superior to single injection nerve block following total knee arthroplasty. Investigators will randomize participants to either continuous nerve block or single injection nerve block for the adductor canal preoperatively. They will assess differences in pain (measured in numeric rating scale), opioid consumption, and physical therapy milestones from postoperative day 0 to 7.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/12/2025
Locations: University of California, San Diego, La Jolla, California
Conditions: Acute Postoperative Pain, Surgery
High Potency Cannabis: Acute and Protracted Effects
Recruiting
The purpose of this research is to assess the effects of smoked cananbis when cannabis is smoked during periods of cannabis use as usual and after a brief period of abstinence.
Gender:
ALL
Ages:
Between 21 years and 55 years
Trial Updated:
06/12/2025
Locations: UCLA Center for Cannabis and Cannabinoids, Los Angeles, California
Conditions: Abuse Cannabis, Pain, Pharmacokinetics
Patient Retrospective Outcomes (PRO)
Recruiting
This study will evaluate de-identified (anonymous) data in subject medical charts to review the clinical outcomes of various treatment approaches in the treatment of chronic pain.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/10/2025
Locations: Kern Neuroscience Institute, Bakersfield, California +10 locations
Conditions: Chronic Pain
1 - 12 of 133